Yield enhancement in whispering gallery mode biosensors: microfluidics and optical forces - Physics > OpticsReport as inadecuate




Yield enhancement in whispering gallery mode biosensors: microfluidics and optical forces - Physics > Optics - Download this document for free, or read online. Document in PDF available to download.

Abstract: A microfluidic whispering gallery mode WGM biosensing system is proposedfor enhanced delivery and detection of target molecules. A microtoroidresonator coupled to a tapered optical fiber is immersed within a microfluidicchannel, and supplied with target molecules at various flow rates. We showthrough Monte Carlo simulations that the flow characteristics and resonantlyenhanced optical forces of the sensor substantially improve both the sensingtime and yield. When compared to a diffusion-limited sensing modality, theaverage time required to detect a single molecule is reduced from more than 100minutes to less than 10 seconds, and the overall yield of the device isenhanced from less than 5% to a maximum of 70.6% for femtomolar concentrationsof analyte.



Author: Kiran Khosla, Jon D. Swaim, Joachim Knittel, Warwick P. Bowen

Source: https://arxiv.org/







Related documents