Synthesis of Chiral Bifunctional ThioUrea N-Heterocyclic CarbenesReport as inadecuate

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Published in: Synlett (ISSN: 0936-5214), p. 881-884 Georg Thieme Verlag, 2010

The rapid and modular synthesis of the first bifunctional N-heterocyclic carbenes bearing a (thio)urea moiety as H-bond donor group was reported. Different analogues could be accessed in seven steps from cheap (S)-pyroglutamic acid in good overall yields (14-30%). The synthesized carbenes were active catalysts in the benzoin reaction.

Keywords: umpolung ; asymmetric catalysis ; carbenes ; homogeneous catalysis ; chiral pool Reference EPFL-ARTICLE-148057doi:10.1055/s-0029-1219543View record in Web of Science

Author: Brand, Jonathan P.; Osuna-Siles, José Ignacio; Waser, Jérôme


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