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Abstract: We investigate the system size dependent rheological response of branchedtype I collagen gels. When subjected to a shear strain, the highlyinterconnected mesh dynamically reorients, resulting in overall stiffening ofthe network. When a continuous shear strain is applied to a collagen network,we observe that the local apparent modulus, in the strain-stiffening regime, isstrongly dependent on the gel thickness. In addition, we demonstrate that theoverall network failure is determined by the ratio of the gel thickness to themesh size. These findings have broad implications for cell-matrix interactions,the interpretation of rheological tissue data, and the engineering ofbiomimetic scaffolds.



Autor: Richard C. Arevalo, Jeffrey S. Urbach, Daniel L. Blair

Fuente: https://arxiv.org/







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