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Improving functional annotation for industrial microbes: a case study with Pichia pastoris


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Publication Date: 2014-06-11

Journal Title: Trends in Biotechnology

Publisher: Elsevier

Language: English

Type: Article

Metadata: Show full item record

Citation: Dikicioglu, D., Wood, V., Rutherford, K. M., McDowall, M. D., & Oliver, S. G. (2014). Improving functional annotation for industrial microbes: a case study with Pichia pastoris. Trends in Biotechnology

Description: This is the published version distributed under a Creative Commons Attribution License 2.0, which can also be found on the publisher's website at: http://www.sciencedirect.com/science/article/pii/S0167779914001061#

Abstract: The research communities studying microbial model organisms, such as Escherichia coli or Saccharomyces cerevisiae, are well served by model organism databases that have extensive functional annotation. However, this is not true of many industrial microbes that are used widely in biotechnology. In this Opinion piece, we use Pichia (Komagataella) pastoris to illustrate the limitations of the available annotation. We consider the resources that can be implemented in the short term both to improve Gene Ontology (GO) annotation coverage e based on annotation transfer, and to establish curation pipelines for the literature corpus of this organism.

Keywords: Pichia pastoris, Komagataella pastoris, industrial microbes, functional annotation, recombinant protein production

Sponsorship: We gratefully acknowledge funding from the Wellcome Trust (PomBase and Canto; WT090548MA to SGO), and the EU 7th Framework Programme (BIOLEDGE Contract No: 289126 to SGO).

Identifiers:

This record's URL: http://dx.doi.org/10.1016/j.tibtech.2014.05.003http://www.repository.cam.ac.uk/handle/1810/245451

Rights: Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Dikicioglu, DuyguWood, ValerieRutherford, Kim M.McDowall, Mark D.Oliver, Stephen G.

Fuente: https://www.repository.cam.ac.uk/handle/1810/245451



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