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Gold Nanoparticles Functionalised with Fast Water Exchanging Gd3  Chelates: Linker Effects on the Relaxivity


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Publication Date: 2015-01-22

Journal Title: Dalton Transactions

Publisher: Royal Society of Chemistry

Volume: 44

Pages: 4016-4031

Language: English

Type: Article

Metadata: Show full item record

Citation: Ferreira, M. F., Gonçalves, J., Mousavi, B., Prata, M. I. M., Rodrigues, S. P. J., Calle, D., López-Larrubia, P., et al. (2015). Gold Nanoparticles Functionalised with Fast Water Exchanging Gd3+ Chelates: Linker Effects on the Relaxivity. Dalton Transactions, 44 4016-4031.

Description: This is the accepted manuscript. The final version is available at http://dx.doi.org/10.1039/C4DT03210A

Abstract:  

Keywords: Gold nanoparticles, Gd3+ chelates, Contrast Agents, MRI, linkers, ω-thiol functionalized DO3A-N-(α-amido)propionate chelators, fast water exchange, stability, biodistribution, in vivo MRI

Sponsorship: This work was financially supported by Fundação para a Ciência e a Tecnologia, Portugal: PhD grant SFRH/BD/63994/2009 to Miguel Ferreira and Sabbatical Grant SFRH/BSAB/1328/2013 to José Martins at Bath University, UK; and Rede Nacional de NMR (REDE/1517/RMN/2005) for the acquisition of the Varian VNMRS 600 NMR spectrometer in Coimbra. T.B.R. was supported by a Marie Curie Fellowship (FP/- PEOPLE-2009-IEF 254380) and an EMBO Fellowship (ALTF 1145-2009). Financial support from Ministerio de Ciencia e Innovación, Spain, projects SAF2011-23622 (S.C.) and CTQ2010-20960-C02-02 (P.L.-L.), and Comunidad de Madrid, Spain, project S2010/BMD-2349 (S.C. and P.L.-L), is also acknowledged. B. Mousavi and L. Helm acknowledge financial support by the Swiss National Science Foundation. This work was carried out in the frame of the COST D38 Action “Metal Based Systems for Molecular Imaging” and COST TD1004 Action “Theranostics Imaging and Therapy”.

Identifiers:

This record's URL: http://dx.doi.org/10.1039/C4DT03210Ahttp://www.repository.cam.ac.uk/handle/1810/248816





Autor: Ferreira, Miguel F.Gonçalves, JanainaMousavi, B.Prata, M. I. M.Rodrigues, S. P. J.Calle, DanielLópez-Larrubia, PilarCerdan, Seba

Fuente: https://www.repository.cam.ac.uk/handle/1810/248816



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