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Glycolysis and the significance of lactate in traumatic brain injury.


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Publication Date: 2015-04-08

Journal Title: Frontiers in Neuroscience

Publisher: Frontiers

Volume: 9

Number: 112

Language: English

Type: Article

Metadata: Show full item record

Citation: Carpenter, K. L. H., Jalloh, I., & Hutchinson, P. J. (2015). Glycolysis and the significance of lactate in traumatic brain injury

Frontiers in Neuroscience, 9 (112)

Description: This is the final version of the article. It first appeared from Frontiers via http://dx.doi.org/10.3389/fnins.2015.00112

Abstract: In traumatic brain injury (TBI) patients, elevation of the brain extracellular lactate concentration and the lactate/pyruvate ratio are well-recognized, and are associated statistically with unfavorable clinical outcome. Brain extracellular lactate was conventionally regarded as a waste product of glucose, when glucose is metabolized via glycolysis (Embden-Meyerhof-Parnas pathway) to pyruvate, followed by conversion to lactate by the action of lactate dehydrogenase, and export of lactate into the extracellular fluid. In TBI, glycolytic lactate is ascribed to hypoxia or mitochondrial dysfunction, although the precise nature of the latter is incompletely understood. Seemingly in contrast to lactate's association with unfavorable outcome is a growing body of evidence that lactate can be beneficial. The idea that the brain can utilize lactate by feeding into the tricarboxylic acid (TCA) cycle of neurons, first published two decades ago, has become known as the astrocyte-neuron lactate shuttle hypothesis. Direct evidence of brain utilization of lactate was first obtained 5 years ago in a cerebral microdialysis study in TBI patients, where administration of 13C-labeled lactate via the microdialysis catheter and simultaneous collection of the emerging microdialysates, with 13C NMR analysis, revealed 13C labeling in glutamine consistent with lactate utilization via the TCA cycle. This suggests that where neurons are too damaged to utilize the lactate produced from glucose by astrocytes, i.e., uncoupling of neuronal and glial metabolism, high extracellular levels of lactate would accumulate, explaining the association between high lactate and poor outcome. Recently, an intravenous exogenous lactate supplementation study in TBI patients revealed evidence for a beneficial effect judged by surrogate endpoints. Here we review the current state of knowledge about glycolysis and lactate in TBI, how it can be measured in patients, and whether it can be modulated to achieve better clinical outcome.

Keywords: traumatic brain injury (human), cerebral energy metabolism, glycolysis, lactate, pyruvate, glucose, microdialysis

Sponsorship: We gratefully acknowledge financial support as follows. Research support: the Medical Research Council (MRC, Grant Nos. G0600986 ID79068 and G1002277 ID98489) and the National Institute for Health Research Biomedical Research Centre (NIHR BRC) Cambridge (Neuroscience Theme; Brain Injury and Repair Theme). Authors' support: KLHC—NIHR BRC Cambridge (Neuroscience Theme; Brain Injury and Repair Theme); IJ—MRC (Grant no. G1002277 ID 98489) and NIHR BRC Cambridge; PJH—NIHR Research Professorship, Academy of Medical Sciences/Health Foundation Senior Surgical Scientist Fellowship, and the NIHR BRC Cambridge

Identifiers:

This record's URL: http://dx.doi.org/10.3389/fnins.2015.00112http://www.repository.cam.ac.uk/handle/1810/247909

Rights: Attribution 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Carpenter, Keri L. H.Jalloh, IbrahimHutchinson, Peter J.

Fuente: https://www.repository.cam.ac.uk/handle/1810/247909



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