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Glycan complexity dictates microbial resource allocation in the large intestine


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Publication Date: 2015-06-26

Journal Title: Nature Communications

Publisher: NPG

Volume: 6

Number: 7481

Language: English

Type: Article

Metadata: Show full item record

Citation: Rogowski, A., Briggs, J. A., Mortimer, J. C., Tryfona, T., Terrapon, N., Lowe, E. C., Basle, A., et al. (2015). Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications, 6 (7481)

Description: This is the final version. It was first published by NPG at http://dx.doi.org/10.1038/ncomms8481

Abstract: The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota.

Keywords: Biological sciences, Biochemistry, Microbiology

Sponsorship: This work was supported in part by grants to D.N.B. (BBSRC BB/G016186/1) and H.J.G. (Wellcome Trust WT097907AIA).

Identifiers:

This record's URL: http://dx.doi.org/10.1038/ncomms8481http://www.repository.cam.ac.uk/handle/1810/249062

Rights: Attribution 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Rogowski, ArturBriggs, Jonathon A.Mortimer, Jennifer C.Tryfona, TheodoraTerrapon, NicolasLowe, Elisabeth C.Basle, ArnaudMorland, C

Fuente: https://www.repository.cam.ac.uk/handle/1810/249062



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