Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findingsReportar como inadecuado


Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings


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Publication Date: 2014-11-21

Journal Title: Metabolic Brain Disease

Publisher: Springer

Volume: 30

Issue: 3

Pages: 615-632

Language: English

Type: Article

Metadata: Show full item record

Citation: Jalloh, I., Carpenter, K. L. H., Helmy, A., Carpenter, T. A., Menon, D. K., & Hutchinson, P. J. (2014). Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings. Metabolic Brain Disease, 30 (3), 615-632.

Description: This is the final published version. It originally appeared at http://dx.doi.org/10.1007/s11011-014-9628-y.

Abstract: The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into the brain and its subsequent metabolism. We review the methods used to study cerebral glucose metabolism with a focus on those used in clinical TBI studies. Arterio-venous measurements provide a global measure of glucose uptake into the brain. Microdialysis allows the in vivo sampling of brain extracellular fluid and is well suited to the longitudinal assessment of metabolism after TBI in the clinical setting. A recent novel development is the use of microdialysis to deliver glucose and other energy substrates labelled with carbon-13, which allows the metabolism of glucose and other substrates to be tracked. Positron emission tomography and magnetic resonance spectroscopy allow regional differences in metabolism to be assessed. We summarise the data published from these techniques and review their potential uses in the clinical setting.

Keywords: 13C labelling, glucose, magnetic resonance spectroscopy, microdialysis, positron emission tomography, traumatic brain injury

Identifiers:

This record's URL: http://dx.doi.org/10.1007/s11011-014-9628-yhttp://www.repository.cam.ac.uk/handle/1810/246457

Rights: Attribution 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Jalloh, IbrahimCarpenter, Keri L. H.Helmy, AdelCarpenter, T. AdrianMenon, David K.Hutchinson, Peter J.

Fuente: https://www.repository.cam.ac.uk/handle/1810/246457



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