Glucocorticoid-induced hyperglycaemia in respiratory disease: a systematic review and meta-analysisReportar como inadecuado


Glucocorticoid-induced hyperglycaemia in respiratory disease: a systematic review and meta-analysis


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Publication Date: 2016-07-08

Journal Title: Diabetes, Obesity and Metabolism

Publisher: Wiley

Language: English

Type: Article

This Version: VoR

Metadata: Show full item record

Citation: Breakey, S., Sharp, S. J., Adler, A. I., & Challis, B. G. (2016). Glucocorticoid-induced hyperglycaemia in respiratory disease: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism https://doi.org/10.1111/dom.12739

Description: This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/dom.12739

Abstract: The relative risk of glucocorticoid-induced hyperglycaemia is poorly quantified. We undertook a meta-analysis to estimate the association between glucocorticoid treatment and hyperglycaemia, overall and separately in individuals with and without diabetes and underlying respiratory disease. We searched electronic databases for clinical trials of adults randomized to either glucocorticoid treatment or placebo. Eight articles comprising 2121 participants were identified. We performed a random effects meta-analysis to determine relative risks for the associations between glucocorticoid use and both hyperglycaemia and starting hypoglycaemic therapy. In all individuals, the relative risk of hyperglycaemia comparing glucocorticoid treatment with placebo was 1.72 [95% confidence interval (CI) 1.50-2.04; p < .001]. The relative risks in individuals with and those without diabetes were 2.10 (95% CI 0.92-5.02; p = .079) and 1.50 (95% CI 0.79-2.86; p = .22), respectively. In all individuals, the relative risk of hyperglycaemia requiring initiation of hypoglycaemic therapy, comparing glucocorticoid treatment with placebo, was 1.73 (95% CI 1.40-2.14; p < .001). In conclusion, glucocorticoid therapy increases the risk of hyperglycaemia in all individuals with underlying respiratory disease but not when diabetic status is analysed separately.

Keywords: endocrine therapy, glycaemic control, meta-analysis

Sponsorship: Medical Research Council (Grant ID: MC_UU_12015/1)

Embargo Lift Date: 2100-01-01

Identifiers:

External DOI: https://doi.org/10.1111/dom.12739

This record's URL: https://www.repository.cam.ac.uk/handle/1810/257325



Rights: Attribution 4.0 International

Licence URL: http://creativecommons.org/licenses/by/4.0/





Autor: Breakey, S.Sharp, S. J.Adler, A. I.Challis, B. G.

Fuente: https://www.repository.cam.ac.uk/handle/1810/257325



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