Gamma delta T-cell large granular lymphocyte lymphoma in a dogReportar como inadecuado


Gamma delta T-cell large granular lymphocyte lymphoma in a dog


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Publication Date: 2015-05-12

Journal Title: Veterinary Clinical Pathology

Publisher: Wiley

Volume: 44

Issue: 3

Pages: 442-447

Language: English

Type: Article

Metadata: Show full item record

Citation: Ortiz, A. L., Carvalho, S., Leo, C., Riondato, F., Archer, J., & Cian, F. (2015). Gamma delta T-cell large granular lymphocyte lymphoma in a dog. Veterinary Clinical Pathology, 44 (3), 442-447.

Description: This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/vcp.12265

Abstract: A 2-year and 6-month-old female neutered Labrador Retriever with Horner syndrome, megaesophagus, and a mediastinal mass was referred to the Queen Mother Hospital for Animals of the Royal Veterinary College. A large granular lymphocyte (LGL) lymphoma was diagnosed on cytology; flow cytometric analysis revealed a γδ T-cell phenotype (CD3+, CD5+, CD45+, TCRγδ+, CD4−, CD8−, CD34−, CD21−). Chemotherapy was started with a combination of lomustine, vincristine, procarbazine, and prednisolone, followed by bleyomicin. Euthanasia was elected by the owners, due to progressive deterioration and lack of quality of life, 28 days after diagnosis. This is the first cytologic and immunophenotypic characterization of a canine γδ T-cell lymphoma with LGL morphology and probably of mediastinal origin. The role of chemotherapy in delaying the disease progression remains unknown.

Keywords: Canine, flow cytometry, immunophenotyping, lymphoid tumor

Identifiers:

This record's URL: http://dx.doi.org/10.1111/vcp.12265http://www.repository.cam.ac.uk/handle/1810/247952





Autor: Ortiz, Ana LizaCarvalho, SofiaLeo, ChiaraRiondato, FulvioArcher, JoyCian, Francesco

Fuente: https://www.repository.cam.ac.uk/handle/1810/247952



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