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G-quadruplex ligands exhibit differential G-tetrad selectivity


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Publication Date: 2015-04-03

Journal Title: Chemical Communications

2015

Publisher: RSC

Volume: 51

Pages: 8048-8050

Language: English

Type: Article

Metadata: Show full item record

Citation: Le, D. D., Di Antonio, M., Chan, L. K. M., & Balasubramanian, S. (2015). G-quadruplex ligands exhibit differential G-tetrad selectivity. Chemical Communications, 51 8048-8050.

Description: This is the final published version. It was first made available by RSC at http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/c5cc02252e#!divAbstract.

Abstract: A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.

Sponsorship: This work was supported by the following grants: Cancer Research UK Programme, BBSRC BB/K018043/1 and EPSRC EP/ K039520/1. We thank Dr Chris Lowe for his constructive comments and for proofreading the manuscript.

Identifiers:

This record's URL: http://dx.doi.org/10.1039/C5CC02252Ehttp://www.repository.cam.ac.uk/handle/1810/248056

Rights: Attribution 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Le, D. D.Di Antonio, M.Chan, L. K. M.Balasubramanian, Shankar

Fuente: https://www.repository.cam.ac.uk/handle/1810/248056



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