Epigenetic determinants of metastasis.

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Publication Date: 2016-10-08
Journal Title: Molecular Oncology
ISSN: 1574-7891
Publisher: Elsevier
Language: English
Type: Article
This Version: VoR
Physical Medium: Print-Electronic
Metadata: Show full item record
Citation: Patel, S. A., & Vanharanta, S. (2016). Epigenetic determinants of metastasis
Molecular Oncology https://doi.org/10.1016/j.molonc.2016.09.008
Abstract: Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer clones display stable traits that can facilitate progression through the many steps of metastasis. How cancer cells establish and maintain the transcriptional programmes required for metastasis remains mostly unknown. Emerging evidence suggests that metastatic traits may arise from epigenetically altered transcriptional output of the oncogenic signals that drive tumour initiation and early progression. Molecular dissection of such mechanisms remains a central challenge for a comprehensive understanding of the origins of metastasis.
Sponsorship: Medical Research Council
Embargo Lift Date: 2100-01-01
Identifiers:
External DOI: https://doi.org/10.1016/j.molonc.2016.09.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261431
Rights: Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
Autor: Patel, Saroor AshfaqVanharanta, Sakari
Fuente: https://www.repository.cam.ac.uk/handle/1810/261431