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Epigenetic determinants of metastasis.

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Publication Date: 2016-10-08

Journal Title: Molecular Oncology

ISSN: 1574-7891

Publisher: Elsevier

Language: English

Type: Article

This Version: VoR

Physical Medium: Print-Electronic

Metadata: Show full item record

Citation: Patel, S. A., & Vanharanta, S. (2016). Epigenetic determinants of metastasis

Molecular Oncology https://doi.org/10.1016/j.molonc.2016.09.008

Abstract: Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer clones display stable traits that can facilitate progression through the many steps of metastasis. How cancer cells establish and maintain the transcriptional programmes required for metastasis remains mostly unknown. Emerging evidence suggests that metastatic traits may arise from epigenetically altered transcriptional output of the oncogenic signals that drive tumour initiation and early progression. Molecular dissection of such mechanisms remains a central challenge for a comprehensive understanding of the origins of metastasis.

Sponsorship: Medical Research Council

Embargo Lift Date: 2100-01-01


External DOI: https://doi.org/10.1016/j.molonc.2016.09.008

This record's URL: https://www.repository.cam.ac.uk/handle/1810/261431

Rights: Attribution 4.0 International

Licence URL: http://creativecommons.org/licenses/by/4.0/

Autor: Patel, Saroor AshfaqVanharanta, Sakari

Fuente: https://www.repository.cam.ac.uk/handle/1810/261431


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