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Abstract: The intrinsic stochasticity of gene expression can lead to large variabilityof protein levels across a population of cells. Variability or noise inprotein distributions can be modulated by cellular mechanisms of generegulation; in particular, there is considerable interest in understanding therole of post-transcriptional regulation. To address this issue, we propose andanalyze a stochastic model for post-transcriptional regulation of geneexpression. The analytical solution of the model provides insight into theeffects of different mechanisms of post-transcriptional regulation on the noisein protein distributions. The results obtained also demonstrate how differentsources of intrinsic noise in gene expression can be discriminated based onobservations of regulated protein distributions.



Autor: Tao Jia, Rahul V. Kulkarni

Fuente: https://arxiv.org/







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