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Confidence and Psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade


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Publication Date: 2015-06-02

Journal Title: Molecular Psychiatry

Publisher: Nature Publishing Group

Language: English

Type: Article

Metadata: Show full item record

Citation: Vinckier, F., Gaillard, R., Palminteri, S., Rigoux, L., Salvador, A., Fornito, A., Adapa, R., et al. (2015). Confidence and Psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade. Molecular Psychiatry

Description: This is the final version of the article. It first appeared from the Nature Publishing Group via http://dx.doi.org/10.1038/mp.2015.73

Abstract: A state of pathological uncertainty about environmental regularities might represent a key step in the pathway to psychotic illness. Early psychosis can be investigated in healthy volunteers under ketamine, an NMDA receptor antagonist. Here, we explored the effects of ketamine on contingency learning using a placebo-controlled, double-blind, cross-over design. During fMRI, participants performed an instrumental learning task in which cue-outcome contingencies were probabilistic and reversed between blocks. Bayesian model comparison indicated that in such an unstable environment, reinforcement learning parameters are down-regulated depending on confidence level, an adaptive mechanism that was specifically disrupted by ketamine administration. Drug effects were underpinned by altered neural activity in a fronto-parietal network, which reflected the confidence-based shift to exploitation of learned contingencies. Our findings suggest that an early characteristic of psychosis lies in a persistent doubt that undermines the stabilization of behavioral policy resulting in a failure to exploit regularities in the environment.

Keywords: reinforcement learning, computational models fMRI, NMDA, ketamine, schizophrenia, psychosis, psychiatry

Sponsorship: FV was supported by the Groupe Pasteur Mutualité. RG was supported by the Fondation pour la Recherche Médicale and the Fondation Bettencourt Schueller. SP is supported by a Marie Curie Intra-European fellowship (FP7-PEOPLE-2012-IEF). AF was supported by National Health and Medical Research Council grants (IDs : 1050504 and 1066779) and an Australian Research Council Future Fellowship (ID: FT130100589). This work was supported by the Wellcome Trust and the Bernard Wolfe Health Neuroscience Fund.

Identifiers:

This record's URL: http://www.repository.cam.ac.uk/handle/1810/248161http://dx.doi.org/10.1038/mp.2015.73

Rights: Attribution 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Vinckier, FabienGaillard, RaphaëlPalminteri, StefanoRigoux, LionelSalvador, AlexandreFornito, AlexAdapa, RamKrebs, Marie-OdilePes

Fuente: https://www.repository.cam.ac.uk/handle/1810/248161



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