Concerted bioinformatic analysis of genome-scale blood transcription factor compendium reveals new control mechanismsReportar como inadecuado


Concerted bioinformatic analysis of genome-scale blood transcription factor compendium reveals new control mechanisms


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Publication Date: 2014-08-11

Journal Title: Molecular Biosystems

Publisher: RSC

Volume: 10

Pages: 2935-2941

Language: English

Type: Article

Metadata: Show full item record

Citation: Joshi, A., & Gottgens, B. (2014). Concerted bioinformatic analysis of genome-scale blood transcription factor compendium reveals new control mechanisms. Molecular Biosystems, 10 2935-2941.

Description: This is the final published version as published by the Royal Society of Chemistry in Molecular Biosystems here: http://pubs.rsc.org/en/Content/ArticleLanding/2014/MB/C4MB00354C#divAbstract.

Abstract: Transcription factors play a key role in development and disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many important discoveries, the rapidly increasing number of publicly available ChIP-sequencing data sets still remains a largely unexplored resource. Using a compendium of 144 publicly available murine ChIP-sequencing data sets in blood, we show that systematic bioinformatic analysis can unravel diverse aspects of transcription regulation; from genome-wide binding preferences, finding regulatory partners and assembling regulatory complexes, to identifying novel functions of transcription factors and investigating transcription dynamics during development.

Identifiers:

This record's URL: http://www.repository.cam.ac.uk/handle/1810/246064http://dx.doi.org/10.1039/c4mb00354c

Rights: Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK

Licence URL: http://creativecommons.org/licenses/by/2.0/uk/





Autor: Joshi, AnaghaGottgens, Berthold

Fuente: https://www.repository.cam.ac.uk/handle/1810/246064



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