Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continentReportar como inadecuado


Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent


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Publication Date: 2015-10-08

Journal Title: Science

Publisher: AAAS

Volume: 350

Pages: 820-822

Language: English

Type: Article

Metadata: Show full item record

Citation: Llorente, M. G., Jones, E. R., Eriksson, A., Siska, V., Arthur, K. W., Arthur, J. W., Curtis, M. C., et al. (2015). Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent. Science, 350 820-822.

Description: This is the author accepted manuscript. The final version is available from AAAS via http://dx.doi.org/10.1126/science.aad2879

Abstract: Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5× coverage ancient genome of an Ethiopian male (“Mota”) who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.

Sponsorship: A.M. was supported by European Research Council (ERC) Consolidator Grant 647787 “LocalAdaptation”; R.P by ERC Starting Grant 263441, “ADNABIOARC”; M.H. by ERC Consolidator Grant 310763 “GeneFlow”; J.B. by the 2014 Research Fund (1.140113.01, 1.140064.01) of UNIST (Ulsan National Institute of Science and Technology) and Geromics internal research funding; J.T.S. by ERC Consolidator Grant 617627 “ADaPt”; K.W.A. by NSF award 1027607; D.G.B. by ERC Investigator Grant 295729-CodeX; V.S. by a scholarship from the Gates Cambridge Trust; and M.G.L. by a Biotechnology and Biological Sciences Research Council (BBSRC) DTP studentship. Permission for the archaeology was given by the Ethiopian Authority for Research and Conservation of Cultural Heritage and offices of the Ministry of Culture and Tourism for the Southern Nations, Nationalities, and Peoples Region. Raw reads from Mota are available for download through the National Center for Biotechnology Information, BioProject ID PRJNA295861, and the corresponding BAM and VCF files are available at africangenome.org

Identifiers:

This record's URL: http://dx.doi.org/10.1126/science.aad2879https://www.repository.cam.ac.uk/handle/1810/252866





Autor: Llorente, M. GallegoJones, E. R.Eriksson, A.Siska, V.Arthur, K. W.Arthur, J. W.Curtis, M. C.Stock, J. T.Coltorti, M.Pieruccini, P.

Fuente: https://www.repository.cam.ac.uk/handle/1810/252866



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