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Anaplastic large cell lymphoma in paediatric and young adult patients


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Publication Date: 2016-02-23

Journal Title: British Journal of Haematology

Publisher: Wiley

Language: English

Type: Article

Metadata: Show full item record

Citation: Turner, S. T., Lamant, L., Kenner, L., & Brugières, L. (2016). Anaplastic large cell lymphoma in paediatric and young adult patients. British Journal of Haematology

Description: This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1111/bjh.13958

Abstract: Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin, which in children is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK activity induced following the formation of chromosomal translocations. Whilst the survival rates for this disease are relatively high, a large proportion of patients suffer disease relapse, in some cases on multiple occasions and therefore suffer the toxic side-effects of combination chemotherapy. Traditionally, patients are treated with a combination of agents although recent data from relapse patients have suggested that low risk patients might benefit from single agent vinblastine and going forward the addition of ALK inhibitors to the therapeutic regimen may have beneficial consequences. There are also a plethora of other drugs that might be advantageous to patients with ALCL and many of these have been identified through laboratory research although the decision as to which drugs to implement in trials will not be trivial.

Keywords: anaplastic large cell lymphoma, anaplastic lymphoma kinase, T cell lymphoma, ALK inhibitors

Sponsorship: Supported in part by the Pediatric Cancer Research Foundation and Fondazione Giacomo Ascoli. S.D.T. is supported with funding from Bloodwise

Identifiers:

This record's URL: https://www.repository.cam.ac.uk/handle/1810/253156http://dx.doi.org/10.1111/bjh.13958





Autor: Turner, Suzanne T.Lamant, LaurenceKenner, LukasBrugières, Laurence

Fuente: https://www.repository.cam.ac.uk/handle/1810/253156



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