Vol 15: Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity.Reportar como inadecuado



 Vol 15: Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity.


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This article is from International Journal of Molecular Sciences, volume 15.AbstractAcetylcholinesterase AChE inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase BChE. Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a -cholinergic anti-inflammatory pathway- which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system.



Autor: Pohanka, Miroslav

Fuente: https://archive.org/







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