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 Vol 10: HIV integration and T cell death: additional commentary.


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This article is from Retrovirology, volume 10.AbstractEstaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498:376-379, 2013). They have raised several hypothetical points that we further clarify here.



Autor: Cooper, Arik; Garcia, Mayra; Petrovas, Constantinos; Yamamoto, Takuya; Koup, Richard A; Nabel, Gary J

Fuente: https://archive.org/



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