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 Vol 6: Fiber intake and inflammation in type 1 diabetes.


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This article is from Diabetology & Metabolic Syndrome, volume 6.AbstractBackground: Higher intake of dietary fiber is associated with lower risk of coronary heart disease, the leading cause of mortality among people with type 1 diabetes. The protective effect includes the anti-inflammatory properties of some foods. Population-based studies have shown an inverse association between some nutritional habits and high sensitive -C-reactive protein (hs-CRP). This study aimed to ascertain the association between fiber intake and hs-CPR levels in patients with type 1 diabetes. Methods: This cross-sectional study was conducted with 106 outpatients with type 1 diabetes; age 40 ± 11 years; diabetes duration of 18 ± 8.8 years. Dietary intake was evaluated by 3-day weighed-diet records. Patients were categorized in 2 groups, according to fiber intake (>20 g-day and  20 g-day had lower hs-CRP levels median (25th-75th) 0.7 mg-dl (0.4-2.4) vs. 1.9 mg-dl (1.0-4.4); P = 0.002, than the other group. Controlled for HbA1c and energy intake, an inverse relation was observed between hs-CRP levels and total fiber ß = − 0.030 (SE: 0.0120), P = 0.02, soluble fiber ß = − 0.078 (SE: 0.0421), P = 0.06 and insoluble fiber ß = − 0.039 (SE: 0.01761), P = 0.026. Even, after additional adjustment fibers remained associated with lower hs-CRP levels. Total fibers were stratified in 4 groups: < 10 g-day, from 10 to  30 g-day. Compared to the group who ingested  30 g-d had significantly lower hs-CRP levels −2.45 mg-L, P = 0.012 independent of the HbA1c values. Conclusions: The present study suggests that an increased consumption of dietary fiber > 30 g-day may play a role in reducing inflammation in individuals with type 1 diabetes.



Autor: Bernaud, Fernanda S R; Beretta, Mileni Vanti; do Nascimento, Ciglea; Escobar, Fabricia; Gross, Jorge L; Azevedo, Mirela J; Rodrigues, Ticiana C

Fuente: https://archive.org/







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