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Felipe Medrano ; Margarita I. Bernal-Uruchurtu ; Carolina Godoy-Alcántar ;Journal of the Mexican Chemical Society 2009, 53 (4)

Autor: Sharon Rosete-Luna

Fuente: http://www.redalyc.org/


Introducción



Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Rosete-Luna, Sharon; Medrano, Felipe; Bernal-Uruchurtu, Margarita I.; Godoy-Alcántar, Carolina Crown Ether Ditopic Receptors for Ammonium Salts with High Affinity for Amino Acid Ester Salts Journal of the Mexican Chemical Society, vol.
53, núm.
4, octubre-diciembre, 2009, pp.
209-219 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47512356002 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Article J.
Mex.
Chem.
Soc.
2009, 53(4), 209-219 © 2009, Sociedad Química de México ISSN 1870-249X Crown Ether Ditopic Receptors for Ammonium Salts with High Affinity for Amino Acid Ester Salts Sharon Rosete-Luna, Felipe Medrano, Margarita I.
Bernal-Uruchurtu, and Carolina Godoy-Alcántar* Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, México. Tel-Fax: 52 777329 7997, cga@uaem.mx Received August 13, 2009; accepted November 19, 2009 Abstract.
Two bis crown ether receptors were synthesized and tested as host molecules for protonated forms of alkyl amines and amino acid esters.
Molecular recognition studies were conducted in CH2Cl2:MeOH (92:8) by spectrophotometric UV-Vis titrations and by spectrometric 1H NMR titrations in CDCl3.
The calculated binding constants are in the range 102-105 M-1.
A high affinity for L-amino acid methyl ester derivatives was found.
A theoretical study at the DFT level of the synthesized receptor and some analog ligands with three different ammonium ions helps to rationalize the experimentally found trends. Key words: Ditopic Receptors, Binding Constant; Crown Ethers, Alkyl Ammon...





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