Substituted pyridopyrimidinones. part 3. synthesis of some novel ether derivatives of 4h-pyrido1,2-apyrimidin-4-one Reportar como inadecuado




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Mostafa M. Ismail ; Wafaa R. Abdel-Monem ; Aisha S. Mayas ;Journal of the Mexican Chemical Society 2009, 53 (2)

Autor: Mohamed Abass

Fuente: http://www.redalyc.org/


Introducción



Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Abass, Mohamed; Ismail, Mostafa M.; Abdel-Monem, Wafaa R.; Mayas, Aisha S. Substituted Pyridopyrimidinones.
Part 3.
Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2a]pyrimidin-4-one Journal of the Mexican Chemical Society, vol.
53, núm.
2, 2009, pp.
48-54 Sociedad Química de México Distrito Federal, México Disponible en: http:--www.redalyc.org-articulo.oa?id=47512080002 Cómo citar el artículo Número completo Más información del artículo Página de la revista en redalyc.org Sistema de Información Científica Red de Revistas Científicas de América Latina, el Caribe, España y Portugal Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto Article J.
Mex.
Chem.
Soc.
2009, 53(2), 48-54 © 2009, Sociedad Química de México ISSN 1870-249X Substituted Pyridopyrimidinones.
Part 3.
Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one Mohamed Abass,* Mostafa M.
Ismail, Wafaa R.
Abdel-Monem, and Aisha S.
Mayas Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11757, Egypt. mabass@chemist.com, quinolinone@yahoo.com Received May 29, 2009; accepted June 25, 2009 Abstract.
A series of novel bis-heterocyclic ethers, containing 4Hpyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4-oxo-4Hpyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetic acid (2) and-or [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetohydrazide (3).
Reaction of ester 1 with some ortho-hydroxy-aldehydes furnished the corresponding pyridopyrimidyloxypyrones.
Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles.
Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3. Key words: Pyrido[1,2-a]pyrimidinone, Ethers, Pyrazoles...





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