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Journal of the Mexican Chemical Society 2009, 53 (1)

Autor: Ramanarayanan Krishnamurthy

Fuente: http://www.redalyc.org/


Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Krishnamurthy, Ramanarayanan A Search for Structural Alternatives of RNA Journal of the Mexican Chemical Society, vol.
53, núm.
1, enero-marzo, 2009, pp.
23-33 Sociedad Química de México Distrito Federal, México Disponible en: http:--www.redalyc.org-articulo.oa?id=47512075005 Cómo citar el artículo Número completo Más información del artículo Página de la revista en redalyc.org Sistema de Información Científica Red de Revistas Científicas de América Latina, el Caribe, España y Portugal Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto J.
2009, 53(1), 23-33 © 2009, Sociedad Química de México ISSN 1870-249X Account A Search for Structural Alternatives of RNA Ramanarayanan Krishnamurthy The Scripps Research Institute.
10550 North Torrey Pines Road.
La Jolla, CA 92037 USA.
rkrishna@scripps.edu Received February 27, 2009; accepted March 25, 2009 Abstract.
This account describes a search for potentially primordial informational oligomers; the work is the direct outcome of the research program that was initiated by the Eschenmoser group —at ETH Zürich about 20 years ago and was continued at The Scripps Research Institute since 1996— in order to understand the chemical basis on which nucleic acids were chosen by nature as the molecular foundation of its genetic apparatus.
The investigation began with the study of the base-pairing properties of structural alternatives of nucleic acids —constructed from different sugars (hexo- & pentopyranoses and tetrofuranose) retaining the canonical nucleobases and phosphates.
The outcome from these studies led to the conclusion that Watson-Crick type base-pairing is not unique to RNA-DNA, and that it can be compatible with a wide variety of backbone edifice.
This provided the motivation to map the landscape of potentially primordial info...

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