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Munawar A. Munawar ; Affia Tasneem ;Journal of the Mexican Chemical Society 2010, 54 (4)

Autor: Ismat Fatima

Fuente: http://www.redalyc.org/


Introducción



Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Fatima, Ismat; Munawar, Munawar A.; Tasneem, Affia Synthesis and Antithyroid Activity of Some 8- Substituted Purine Derivatives Journal of the Mexican Chemical Society, vol.
54, núm.
4, octubre-diciembre, 2010, pp.
227-232 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47521542008 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Synthesis Article and Antithyroid Activity of Some 8-Substituted Purine Derivatives J.
Mex.
Chem.
Soc.
2010, 54(4), 227-232 227 © 2010, Sociedad Química de México ISSN 1870-249X Synthesis and Antithyroid Activity of Some 8-Substituted Purine Derivatives Ismat Fatima,1 Munawar A.
Munawar1* and Affia Tasneem2 1Institute of Chemistry, University of the Punjab, Lahore-Pakistan Mayo Hospital, Lahore-Pakistan.
mamunawar@chem.pu.edu.pk 2CENUM, Received August 6, 2010; accepted September 9, 2010 Abstract.
Some novel as well as known derivatives of 8-sulfanyl-3,9dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg-kg via i.p.
injection for 15 days.
Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique.
The assay results showed decrease in the hormonal concentrations for the animals treated with these compounds as compared to the control animals.
Similarly, thyroid stimulating hormone level was measured with ELISA method and the results demonstrated a comparative increase of this hormone for the treated animals.
The hormonal variations indicated significant (α≤0.05) activity of the compounds. Histo...





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