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Okram Zenita Devi ;Journal of the Mexican Chemical Society 2010, 54 (4)

Autor: Kanakapura Basavaiah

Fuente: http://www.redalyc.org/


Introducción



Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Basavaiah, Kanakapura; Zenita Devi, Okram Application of Oxidizing Properties of Permanganate to the Determination of Famotidine in Pharmaceutical Formulations Journal of the Mexican Chemical Society, vol.
54, núm.
4, octubre-diciembre, 2010, pp.
182-191 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47521542002 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative J.
Mex.
Chem.
Soc.
2010, 54(4), 182-191 Kanakapura Basavaiah and Química Okram Zenita Devi © 2010, Sociedad de México ISSN 1870-249X 182      J.
Mex.
Chem.
Soc.
2010, 54(4) Article Application of Oxidizing Properties of Permanganate to the Determination of Famotidine in Pharmaceutical Formulations Kanakapura Basavaiah* and Okram Zenita Devi Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, India.
basavaiahk@yahoo.co.in Received February 15, 2010; accepted June 17, 2010 Abstract.
One titrimetric and two spectrophotometric methods are described for the determination of famotidine (FMT) in either pure form or in its pharmaceutical formulations.
The methods are based on redox reaction between FMT and KMnO4 in acid and alkaline media. In titrimetry, an acidified solution of FMT is titrated directly with permanganate.
Direct spectrophotometry (method A) involves treating the alkaline solution of the drug with permanganate and measuring the bluish green product at 610 nm.
In indirect spectrophotometry (method B), the drug solution is treated with a fixed concentration of permanganate in H2SO4 medium, and after a specified time, the unreacted permanganate is measured ...





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