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Kunnummel Veena ;Journal of the Mexican Chemical Society 2010, 54 (2)

Autor: Badiadka Narayana

Fuente: http://www.redalyc.org/


Introducción



Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Narayana, Badiadka; Veena, Kunnummel Spectrophotometric Determination of Citalopram Hydrobromide in Pharmaceuticals Journal of the Mexican Chemical Society, vol.
54, núm.
2, abril-junio, 2010, pp.
98-102 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47519864006 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Article J.
Mex.
Chem.
Soc.
2010, 54(2), 98-102 © 2010, Sociedad Química de México ISSN 1870-249X Spectrophotometric Determination of Citalopram Hydrobromide in Pharmaceuticals Badiadka Narayana* and Kunnummel Veena Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri – 574 199, Karnataka, India.
Fax: 91-824-2287367.
nbadiadka@yahoo.co.uk Received November 11, 2009; accepted April 26, 2010 Abstract.
Simple, rapid and sensitive methods are described for the spectrophotometric determination of citalopram hydrobromide (CIT) in pharmaceuticals.
The method A is based on the oxidation of citalopram by a known excess of bromate-bromide mixture in hydrochloric acid medium, reduction of the residual oxidant by a fixed amount of iron(II) and the formation of iron(III)-thiocyanate-complex which is measured at 480 nm.
In the method B, 1,10-phenanthroline is used as a complexing agent and the formation of iron(II)-1,10-phenanthroline, which is measured at 510 nm.
The system obeys Beer’s law in the concentration range of 1.0-7.0 µg mL-1 of CIT for method A and 0.6-6.2 µg mL-1 of CIT for method B.
No interference observed from common pharmaceutical adjuvants.
Both methods are equally precise as shown by the...





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