Vol 9: C-Abl Inhibitor Imatinib Enhances Insulin Production by Cells: C-Abl Negatively Regulates Insulin Production via Interfering with the Expression of NKx2.2 and GLUT-2.Reportar como inadecuado



 Vol 9: C-Abl Inhibitor Imatinib Enhances Insulin Production by Cells: C-Abl Negatively Regulates Insulin Production via Interfering with the Expression of NKx2.2 and GLUT-2.


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This article is from PLoS ONE, volume 9.AbstractChronic myelogenous leukemia patients treated with tyrosine kinase inhibitor, Imatinib, were shown to have increased serum levels of C-peptide. Imatinib specifically inhibits the tyrosine kinase, c-Abl. However, the mechanism of how Imatinib treatment can lead to increased insulin level is unclear. Sp

Autor: Xia, Chang-Qing; Zhang, Pengcheng; Li, Shiwu; Yuan, Lihui; Xia, Tina; Xie, Chao; Clare-Salzler, Michael J.

Fuente: https://archive.org/







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