Nitro radical anion formation from nitrofuryl substituted 1,4-dihydropyridine derivatives in mixed and non-aqueous mediaReportar como inadecuado




Nitro radical anion formation from nitrofuryl substituted 1,4-dihydropyridine derivatives in mixed and non-aqueous media - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Resumen

Three new nitrofuryl substituted 1,4-dihydropyridine derivatives were electrochemically tested in the scope of newly found compounds useful as chemotherapeutic alternative to the Chagas- disease.All the compounds were capable to produce nitro radical anions sufficiently stabilized in the time window of the cyclic voltammetric experiment. In order to quantify the stability of the nitro radical anion we have calculated the decay constant, k2. Furthermore, from the voltammetric results, some parameters of biological significance as E-71 indicative of in vivo nitro radical anion formation and K-O2 thermodynamic indicator of oxygen redox cycling have been calculated. From the comparison of E-71, K-O2 and k2, values between the studied nitrofuryl 1,4-DHP derivatives and well-known current drugs an auspicious activity for one of the studied compounds i.e. FDHP2, can be expected.



Autor: Argüello da Silva, Jacqueline; - Núñez Vergara, Luis; - Bollo Dragnic, Soledad; - Squella Serrano, Juan; -

Fuente: http://repositorio.uchile.cl/



DESCARGAR PDF




Documentos relacionados