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BMC Cancer

, 9:18

First Online: 14 January 2009Received: 11 January 2008Accepted: 14 January 2009DOI: 10.1186-1471-2407-9-18

Cite this article as: Yili, Z., Xiaoyan, H., Hongwen, D. et al. BMC Cancer 2009 9: 18. doi:10.1186-1471-2407-9-18


BackgroundTo define a threshold value of apparent diffusion coefficient ADC with which malignant breast lesions can be distinguished from benign lesions, and to evaluate the ADC change of peri-tumor tissue in breast carcinoma by echo planar-diffusion weighted imaging EPI-DWI.

Methods57 breast lesions were scanned by routine MRI and EPI-DWI. The ADC values were compared between malignant and benign lesions. The sensitivity and specificity of EPI-DWI and the threshold ADC value were evaluated by Receiver Operating Characteristic curve ROC. The ADC values of malignant lesion and layered peri-tumor tissues from innermost layer 1 to outermost layer 4 with 5 mm every layer in different directions were compared and the ADC values among different layers were compared.

ResultsThe ADC value of 35 malignant lesions was statistically lower than that of 22 benign lesions P < 0.05. In ROC curve, the threshold value was 1.24 +- 0.25*10E-3 mm-s b = 500 or 1.20 +- 0.25*10E-3 mm-s b = 1000. The ADC value of malignant lesions was statistically lower than that of peri-tumor tissues in different directions P < 0.05. For peri-tumor tissues, the ADC values increased gradually from layer 1 to layer 4 and there was a significant difference between the ADC values of layer 1 and layer 2 P < 0.05; while from layer 2 outwards, there was no statistical difference among different layers.

ConclusionADC value was a sensitive and specific parameter that could help to differentiate benign and malignant breast lesions. ADC changes in tissues adjacent to breast carcinoma could be detected by EPI-DWI, which made EPI-DWI a promising method for helping to determine surgical scope of breast carcinoma.

AbbreviationsADCApparent Diffusion Coefficient

DWIDiffusion-Weighted Imaging

MRIMagnetic Resonance Imaging

ROCReceiver Operating Characteristic

ROIRegion Of Interest.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-18 contains supplementary material, which is available to authorized users.

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Autor: Zhang Yili - Huang Xiaoyan - Du Hongwen - Zhang Yun - Chen Xin - Wang Peng - Guo Youmin


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