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Cases Journal

, 2:49

First Online: 13 January 2009Received: 28 November 2008Accepted: 13 January 2009DOI: 10.1186-1757-1626-2-49

Cite this article as: Kranidiotis, G.P., Voidonikola, P.T., Dimopoulos, M.K. et al. Cases Journal 2009 2: 49. doi:10.1186-1757-1626-2-49


BackgroundRenal cell carcinoma is associated with a wide spectrum of para-neoplastic syndromes, which may be precursors of primary or recurrent disease. Non-metastatic hepatic dysfunction in patients suffering from renal cell carcinoma is known as Stauffer-s syndrome. It is associated with the production of cytokines by the tumour, and several biochemical abnormalities, including elevated serum alkaline phosphatase.

Case presentationWe describe a 36-year-old woman presenting with various non-specific, systemic disease manifestations, and elevated liver enzymes due to cholestasis as the main laboratory abnormality. Imaging studies showed a solid mass in the left kidney, which, after surgical excision, was identified as renal cell carcinoma. No metastasis was found.

ConclusionStauffer syndrome may precede other manifestations of renal cell carcinoma. In case of unexplained abnormal liver function, particularly in presence of systemic symptoms, underlying renal cell carcinoma should be excluded by focused investigations.

AbbreviationsRCCRenal cell carcinoma

CTComputed tomographic scan.

Electronic supplementary materialThe online version of this article doi:10.1186-1757-1626-2-49 contains supplementary material, which is available to authorized users.

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Autor: Georgios P Kranidiotis - Paraskevi T Voidonikola - Meletios K Dimopoulos - Maria I Anastasiou-Nana


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