Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism SNP309 in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancerReportar como inadecuado




Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism SNP309 in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 9:13

First Online: 13 January 2009Received: 01 October 2008Accepted: 13 January 2009DOI: 10.1186-1471-2407-9-13

Cite this article as: Sun, YF., Leu, JD., Chen, SM. et al. BMC Cancer 2009 9: 13. doi:10.1186-1471-2407-9-13

Abstract

BackgroundIt has been suggested that the single nucleotide polymorphism 309 SNP309, T -> G in the promoter region of the MDM2 gene is important for tumor development; however, with regards to breast cancer, inconsistent associations have been reported worldwide. It is speculated that these conflicting results may have arisen due to different patient subgroups and ethnicities studied. For the first time, this study explores the effect of the MDM2 SNP309 genotype on Taiwanese breast cancer patients.

MethodsGenomic DNA was obtained from the whole blood of 124 breast cancer patients and 97 cancer-free healthy women living in Taiwan. MDM2 SNP309 genotyping was carried out by restriction fragment length polymorphism RFLP assay. The multivariate logistic regression and the Kaplan-Meier method were used for analyzing the risk association and significance of age at diagnosis among different MDM2 SNP309 genotypes, respectively.

ResultsCompared to the TT genotype, an increased risk association with breast cancer was apparent for the GG genotype OR = 3.05, 95% CI = 1.04 to 8.95, and for the TG genotype OR = 2.12, 95% CI = 0.90 to 5.00 after adjusting for age, cardiovascular disease-diabetes, oral contraceptive usage, and body mass index, which exhibits significant difference between cases and controls. Furthermore, the average ages at diagnosis for breast cancer patients were 53.6, 52 and 47 years for those harboring TT, TG and GG genotypes, respectively. A significant difference in median age of onset for breast cancer between GG and TT+TG genotypes was obtained by the log-rank test p = 0.0067.

ConclusionFindings based on the current sample size suggest that the MDM2 SNP309 GG genotype may be associated with both the risk of breast cancer and an earlier age of onset in Taiwanese women.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-13 contains supplementary material, which is available to authorized users.

Ying-Fang Sun, Jyh-Der Leu contributed equally to this work.

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Autor: Ying-Fang Sun - Jyh-Der Leu - Su-Mei Chen - I-Feng Lin - Yi-Jang Lee

Fuente: https://link.springer.com/







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