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BMC Cancer

, 15:1015

First Online: 26 December 2015Received: 01 May 2015Accepted: 15 December 2015DOI: 10.1186-s12885-015-2015-1

Cite this article as: Kim, B.W., Cho, H., Choi, C.H. et al. BMC Cancer 2015 15: 1015. doi:10.1186-s12885-015-2015-1

Abstracts

BackgroundCancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. Cancer stem cell markers including OCT4 and SOX2 have been found in various solid tumors. Here, we investigate the expression and clinical significance of OCT4 and SOX2 in cervical cancer.

MethodsTo define the clinical significance of OCT4 and SOX2 expression, we performed immunohistochemistry for OCT4 and SOX2 on 305 normal cervical epithelium samples, 289 cervical intraepithelial neoplasia samples, and 161 cervical cancer cases and compared the data with clinicopathologic factors, including survival rates of patients with cervical cancer.

ResultsOCT4 and SOX2 expression was higher in cervical cancer than normal cervix both p < 0.001. OCT4 overexpression was associated with lymphovascular space invasion p = 0.045, whereas loss of SOX2 expression was correlated with large tumor size p = 0.015. Notably, OCT4 and SOX2 were significantly co-expressed in premalignant cervical lesions, but not in malignant cervical tumor. OCT4 overexpression showed worse 5-year disease-free and overall survival rates p = 0.012 and p = 0.021, respectively when compared to the low-expression group, while SOX2 expression showed favorable overall survival p = 0.025. Cox regression analysis showed that OCT4 was an independent risk factor hazard ratio = 11.23, 95 % CI, 1.31 - 95.6; p = 0.027 for overall survival while SOX2 overexpression showed low hazard ratio for death hazard ratio = 0.220, 95 % CI, 0.06–0.72; p = 0.013.

ConclusionsThese results suggest that OCT4 overexpression and loss of SOX2 expression are strongly associated with poor prognosis in patients with cervical cancer.

KeywordsNeoplastic stem cells OCT4 SOX2 Prognosis Survival Uterine cervical neoplasms AbbreviationsADadenocarcinoma

CIconfidence interval

CINcervical intraepithelial neoplasia

CSCcancer stem cell

FIGOInternational Federation of Gynecology and Obstetrics

HandEhematoxylin and eosin

HPVhuman papillomavirus

HRhazard ration

IHCimmunohistochemistry

LNlymph node

LVSIlymphovascular space invasion

OCT-4octamer-binding transcription factor 4: SOX2, sex determining region Y-box 2

ROCreceiver operating characteristic

SCCsquamous cell carcinoma

TMAtissue microarray

WHOWorld Health Organization

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Autor: Bo Wook Kim - Hanbyoul Cho - Chel Hun Choi - Kris Ylaya - Joon-Yong Chung - Jae-Hoon Kim - Stephen M. Hewitt

Fuente: https://link.springer.com/







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