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Systematic Reviews

, 3:72

First Online: 05 July 2014Received: 25 March 2014Accepted: 17 June 2014DOI: 10.1186-2046-4053-3-72

Cite this article as: Falavigna, M., Lima, K.M., Giacomazzi, J. et al. Syst Rev 2014 3: 72. doi:10.1186-2046-4053-3-72


BackgroundThere is no consensus in the literature regarding the effectiveness of lifestyle modification interventions, including recommendations about specific diet or exercise program for patients with breast cancer. Diet interventions and regular physical activity may reduce the risk of breast cancer and its recurrence. The primary aim of our study is to evaluate the effects of different lifestyle modification interventions diet and physical activity in the survival of patients with stages I to III breast cancer after treatment.

Methods-designThis review will be conducted according to the Cochrane Handbook for Systematic Reviews of Intervention and will be reported following the PRISMA statement recommendations. CENTRAL, MEDLINE and EMBASE databases will be searched for peer-reviewed literature. Randomized controlled trials of diet, exercise, or both, compared with usual care, after treatment of breast cancer stage I to III will be included in the systematic review. Two authors will independently screen titles and abstracts of studies for potential eligibility. Data will be combined using random-effect meta-analysis models with restricted maximum-likelihood as variance estimator, and will be presented as relative risk or standardized mean difference with 95% CI. The quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation GRADE framework and summary of findings tables will be presented for patient important outcomes.

DiscussionOur study may improve the current understanding of the role that lifestyle-modifiable factors can play in saving or prolonging the lives of women who have been treated for breast cancer, and also on modifying their quality of life.

Systematic review registrationThe review has been registered with PROSPERO registration number CRD42014008743.

KeywordsBreast cancer Lifestyle interventions Exercise Diet Physical activity Systematic review Adjuvant chemotherapy AbbreviationsAJCCAmerican Joint Committee on Cancer

BMIBody mass index

HER2Human epidermal growth factor receptor 2

HOMA-IRHomeostasis model assessment-estimated insulin resistance

HRHormone receptor

IGF1Insulin-like growth factor 1

IGFBP1Insulin-like growth factor-binding protein 1

IGFBP2Insulin-like growth factor-binding protein 2

SHBGSex hormone-binding globulin.

Electronic supplementary materialThe online version of this article doi:10.1186-2046-4053-3-72 contains supplementary material, which is available to authorized users.

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Autor: Maicon Falavigna - Karine Margarites Lima - Juliana Giacomazzi - Diego d’Avila Paskulin - Luciano Serpa Hammes - Rodrigo

Fuente: https://link.springer.com/

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