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Journal of Medical Case Reports

, 2:316

First Online: 30 September 2008Received: 11 December 2007Accepted: 30 September 2008DOI: 10.1186-1752-1947-2-316

Cite this article as: Meacci, E., Mulè, A., Cesario, A. et al. J Med Case Reports 2008 2: 316. doi:10.1186-1752-1947-2-316


IntroductionWe describe an original case of progressive severe dysphagia caused by a posterior mediastinal metastatic melanoma of unknown origin. To the best of our knowledge, such an event has never been described before in the literature.

Case presentationA progressive severe dysphagia case is reported induced by a melanoma of unknown origin metastatic to a posterior mediastinal lymph node. At the time of diagnosis, the lesion appeared as a large posterior mediastinal mass mimicking a neurogenic tumour with oesophageal involvement. After complete resection, pathological assessment of the tumour by immunohistochemistry was consistent with nodal metastatic melanoma.

ConclusionThis report of a posterior mediastinal lymph node melanoma is unique. The nodal origin is definitely unusual: a primary melanoma should always be carefully ruled out. In fact no other evidence, a part from the absence of the tumour elsewhere, can support the diagnosis of a primary nodal melanoma.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-2-316 contains supplementary material, which is available to authorized users.

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Autor: Elisa Meacci - Antonino Mulè - Alfredo Cesario - Claudia Maggiore - Stefano Margaritora


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