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Molecular and Cellular Therapies

, 2:24

Regenerative Medicine

Abstract

Despite ongoing research efforts and attempts to bring new drugs into trial, the prognosis for brain tumors remains poor. Patients with the most common and lethal intracranial neoplasia, glioblastoma multiforme GBM, have an average survival of one year with combination of surgical resection, radiotherapy and temozolomide. One of the main problems in the treatment of GBM is getting drugs across the blood brain barrier BBB efficiently. In an attempt to solve this problem, there are ongoing experimental and clinical trials to deliver drugs within stem cells. The purpose for this method is the ease by which stem cells home to the brain. This review discusses the experimental and clinical applications of stem cells for GBM. We also discuss the different properties of stem cells. This information is important to understand why one stem cell would be advantageous over another in cell therapy. We provide an overview of the different drug delivery methods, gene-based treatments and cancer vaccines for GBM, including the stem cell subset.

KeywordsStem cells Cell therapy Glioblastoma Cancer Electronic supplementary materialThe online version of this article doi:10.1186-2052-8426-2-24 contains supplementary material, which is available to authorized users.

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Autor: Veronica Mariotti - Steven J Greco - Ryan D Mohan - George R Nahas - Pranela Rameshwar

Fuente: https://link.springer.com/







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