Suitable hepatitis B vaccine for adult immunization in ChinaReportar como inadecuado




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Immunologic Research

, Volume 64, Issue 1, pp 242–250

First Online: 08 December 2015DOI: 10.1007-s12026-015-8742-1

Cite this article as: Yang, L., Yao, J., Li, J. et al. Immunol Res 2016 64: 242. doi:10.1007-s12026-015-8742-1

Abstract

The aim of this study was to evaluate, in adults, the immunogenicity of six hepatitis B vaccines with different doses or different manufacturers in the Chinese market and to provide evidence to support adult hepatitis B vaccination. Participants were randomly divided into six groups I–VI. Six vaccines 4 at 10 μg-dose and 2 at 20 μg-dose were administered intramuscularly to healthy adults at 0, 1 and 6 month intervals. All participants 16–50 years who were negative for any hepatitis B virus serological markers were vaccinated. Anti-HBs levels were assessed 1 month and 1 year after the third vaccination. The anti-HBs seroconversion rate anti-HBs >10mIU-ml was 99.4 % 99.9 % for 10 μg dose groups and 97.9 % for 20 μg dose groups 1 month after the third vaccination, and the anti-HBs seroreversion rate was 77.0 % 75.3 and 82.6 % 1 year after the third vaccination n = 1036. One month after completing the vaccinations, the seroconversion rates were not significantly different 100.0, 100.0, 99.6, 100.0 % for the four 10 μg dose and two 20 μg dose groups 99.1, 96.9 %. One year after the third vaccination, the group II positive rate was significantly higher than the other three 10 μg dose groups, and the group VI positive rate was significantly higher than the other 20 μg dose group. Groups II and VI showed a significantly higher positive rate and anti-HBs geometric mean titer GMT than the other groups. The anti-HBs level declined with increasing age, and the seroreversion rate and GMT decreased over time. All six vaccines had high anti-HBs seroconversion rates and good immunization effects. The 10 μg dose vaccine Dalian High-Tech and the 20 μg dose vaccine GlaxoSmithKline are recommended for adults.

KeywordsAdults Hepatitis B vaccine Vaccine immunogenicity Linna Yang, Jun Yao and Jing Li have contributed equally to this work.

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Autor: Linna Yang - Jun Yao - Jing Li - Yongdi Chen - Zheng-gang Jiang - Jing-jing Ren - Kai-jin Xu - Bing Ruan - Shi-gui Yang -

Fuente: https://link.springer.com/







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