Absence of human herpes virus-8 HHV8 in nephrogenic systemic fibrosisReport as inadecuate

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BMC Research Notes

, 1:82

First Online: 17 September 2008Received: 21 May 2008Accepted: 17 September 2008DOI: 10.1186-1756-0500-1-82

Cite this article as: O-Donnell, P.J., Duke, W.H. & Pantanowitz, L. BMC Res Notes 2008 1: 82. doi:10.1186-1756-0500-1-82


BackgroundNephrogenic systemic fibrosis NSF is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma.

FindingsSkin lesions procured from two male NSF patients were found to be negative for HHV8 LNA-1 by means of immunohistochemsitry.

ConclusionThis finding negates a role for HHV8 in the pathogenesis of NSF.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-1-82 contains supplementary material, which is available to authorized users.

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Author: Patrick J O-Donnell - Wayne H Duke - Liron Pantanowitz

Source: https://link.springer.com/

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