The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase ExpressionReportar como inadecuado




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Journal of Diabetes Research - Volume 2015 2015, Article ID 484721, 8 pages -

Research ArticleGuizhou Medical University, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550025, China

Received 18 February 2015; Revised 29 May 2015; Accepted 1 June 2015

Academic Editor: Bernard Portha

Copyright © 2015 Yu He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Currently there has been no effective treatment of diabetic encephalopathy. Radix Polygoni Multiflori, a famous traditional Chinese medicine, is widely used in antiaging treatment, especially in prevention and treatment of Alzheimer’s diseases. In this study we tried to explore the effect of Radix Polygoni Multiflori on cognitive function among diabetic rats with demonstrated cognitive impairment. SD rats were divided into group A control group, group B diabetes, group C treated with Radix Polygoni Multiflori at the dose of 2 g-kg-d, and group D treated with same drug at the dose of 1 g-kg-d. The results showed that 8 weeks of Radix Polygoni Multiflori treatment could improve the cognitive dysfunction of diabetic rats , recover the ultrastructure of hippocampal neurons, and increase the number of synapses in a dose-dependent manner. Further experiment also suggested that the neuroprotective effect of Radix Polygoni Multiflori was partly achieved by downregulating MLCK expression in hippocampus via ERK signaling.





Autor: Yu He, Feng Wang, Shiqiang Chen, Mi Liu, Wei Pan, and Xing Li

Fuente: https://www.hindawi.com/



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