The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohortReportar como inadecuado

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Journal of Translational Medicine

, 12:254

Cancer microenvironment


BackgroundAngiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 miRNA-126 and microvessel density MVD, in a population based cohort of patients operated for stage II colon cancer.

MethodsA total of 560 patients were included. Analyses were performed on formalin fixed paraffin embedded tissue from the primary tumours. The analysis of miRNA-126 expression was performed by qPCR. Microvessels were visualised by CD105 and quantified in hot spots using a light microscope. The analyses were correlated with recurrence-free cancer specific survival RF-CSS and overall survival OS.

ResultsLow miRNA-126 expression was significantly correlated to T4, high malignancy grade, tumour perforation, fixation, and the presence of microsatellite instability. A prognostic impact on OS was detected in the simple analysis favouring patients with high miRNA-126 expression p = 0.03, and borderline significance as to RF-CSS, p = 0.08. The impact on OS demonstrated borderline significance in a following multiple Cox regression analysis, hazard ratio 0.76 95% confidence interval, 0.58-1.00, p = 0.051. The MVD estimate was not associated with either RF-CSS, p = 0.49, or OS, p = 0.94.

ConclusionThe current population based study of patients operated for stage II colon cancer demonstrated correlations between several prognostic unfavourable characteristics and miRNA-126 and argues for a possible prognostic impact on overall survival. An influence on survival by the MVD estimate was not detected.

KeywordsAngiogenesis Colon cancer Duke’s B microRNA-126 Microvessel density Prognostic markers Electronic supplementary materialThe online version of this article doi:10.1186-s12967-014-0254-6 contains supplementary material, which is available to authorized users.

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Autor: Torben Frøstrup Hansen - Sanne Kjær-Frifeldt - Søren Morgenthaler - Thorarinn Blondal - Jan Lindebjerg - Anders Jakobsen


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