Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USAReportar como inadecuado

Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medicine

, 12:154

Obesity: exploring the causes, consequences and solutions


BackgroundSeveral non-invasive prediction scores for non-alcoholic fatty liver disease NAFLD have been developed, but their performance has not been compared and validated in the same population, and whether these prediction scores can predict clinical outcomes remains unknown. In this study, we aimed to validate and compare the performance of four NAFLD prediction scores: fatty liver index, hepatic steatosis index, lipid accumulation product, and NAFLD liver fat score LFS, and to evaluate the ability of the best NAFLD prediction score to predict mortality.

MethodsWe analyzed data from the National Health and Nutrition Examination Survey conducted in 1988 to 1994, and subsequent follow-up data for mortality up to December 31, 2006. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other known liver diseases.

ResultsIn a group of 5,184 participants, LFS consistently showed the highest area under the curve for predicting the presence of NAFLD. During a median follow-up of 14.7 years range 0.1 to 18.2 years and 83,830.5 person-years, participants in the high LFS group LFS ≥1.257 had a higher cardiovascular and liver-related mortality than participants in the low LFS ≤− 1.413; cardiovascular hazard ratio HR = 2.24, 95% CI 1.03 to 4.88; liver HR = 31.25, 95% CI 3.13 to 333.33 or intermediate -1.413 < LFS < 1.257; cardiovascular HR = 2.3, 95% CI 1.19 to 4.48; liver HR = 30.3, 95% CI 4 to 250 LFS groups in the fully adjusted model. Similar results were obtained when LFS was treated as a continuous variable.

ConclusionsLFS is the best non-invasive prediction score for NAFLD, and people with a high LFS score have an increased risk for cardiovascular and liver-related mortality.

KeywordsNAFLD NAFLD liver fat score Mortality Electronic supplementary materialThe online version of this article doi:10.1186-s12916-014-0154-x contains supplementary material, which is available to authorized users.

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Autor: Ching-Lung Cheung - Karen SL Lam - Ian CK Wong - Bernard MY Cheung


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