Ventriculitis due to Staphylococcus lugdunensis: two case reportsReport as inadecuate

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Journal of Medical Case Reports

, 2:267

First Online: 11 August 2008Received: 03 October 2007Accepted: 11 August 2008DOI: 10.1186-1752-1947-2-267

Cite this article as: Spanu, T., Rigante, D., Tamburrini, G. et al. J Med Case Reports 2008 2: 267. doi:10.1186-1752-1947-2-267


IntroductionStaphylococcus lugdunensis is an unusually virulent coagulase-negative staphylococcus that has rarely been implicated in central nervous system infections.

Case presentationTwo children hospitalized in the Neurosurgery Unit developed ventriculitis caused by methicillin-resistant Staphylococcus lugdunensis following placement of external ventriculostomy drains. The causative organisms were identified by molecular studies. The patients recovered without significant sequelae after high doses of intrathecal vancomycin.

ConclusionDistinguishing Staphylococcus lugdunensis from other coagulase-negative staphylococcus species is crucial because it carries a substantial risk for severe central nervous system infections displayed by patients with implanted cerebrospinal fluid devices. Clinicians should not underestimate the importance of the isolation of this species from cerebrospinal fluid specimens.

AbbreviationsCNSCentral nervous system

CoNSCoagulase-negative staphylococcus

CSFCerebrospinal fluid

EVDExternal ventriculostomy drain


VPSventriculo-peritoneal shunt

MRIMagnetic resonance imaging

PFGEPulsed-field gel electrophoresis.

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Author: Teresa Spanu - Donato Rigante - Gianpiero Tamburrini - Barbara Fiori - Tiziana D-Inzeo - Brunella Posteraro - Domenico Poli


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