Expression profiling identifies novel Hh-Gli-regulated genes in developing zebrafish embryosReportar como inadecuado




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Resumen

The Hedgehog Hh signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh-Gli signaling is amajor causative factor in human congenital disorders and in a variety of cancers. The zebrafish is a powerful genetic model for the study of Hhsignaling during embryogenesis, as a large number of mutants that affect different components of the Hh-Gli signaling system have beenidentified. By performing global profiling of gene expression in different Hh-Gli gain- and loss-of-function scenarios we identified knowne.g., ptc1 and nkx2.2a and novel Hh-regulated genes that are differentially expressed in embryos with altered Hh-Gli signaling function. Byuncovering changes in tissue-specific gene expression, we revealed new embryological processes that are influenced by Hh signaling. We thusprovide a comprehensive survey of Hh-Gli-regulated genes during embryogenesis and we identify new Hh-regulated genes that may be targets ofmisregulation during tumorigenesis.



Autor: Bergeron, Sadie A.; - Milla, Luis A.; - Villegas, Rosario; - Shen, Meng-Chieh; - Burgess, Shawn M.; - Allende Connelly, Miguel; -

Fuente: http://repositorio.uchile.cl/



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