Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryoReportar como inadecuado




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Resumen

The Snail genes are implicated in processes that involve cell movement, both during embryonic development and tumourprogression. In teleosts, the vertebrate Snail1 gene is represented by two distinct genes, snail1a and snail1b previously snail1 andsnail2. These genes are expressed in complementary mesodermal domains and their combined expression matches that of theirmammalian counterpart. By analysing their loss and gain of function, we found that the most-anterior axial mesendodermal cells,the precursors of the polster, move in a cohesive manner directed by the activity of snail1a- and snail1b-expressing cells surroundingthese precursors. The cell-autonomous function of Snail1 proteins regulates cell motility and influences the behaviour of Snailnegativeneighbouring cells. Snail1a is required by the prechordal plate for it to reach its normal position, whereas Snail1b controlsthe acquisition of its normal shape. These non-redundant functions of Snail1a and Snail1b in controlling axial mesendodermmigration comply with the duplication-degeneration-complementation model, and indicate that Snail genes not only act asinducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.



Autor: Blanco, María J.; - Barrallo-Gimeno, Alejandro; - Acloque, Hervé; - Reyes, Ariel E.; - Tada, Masazumi; - Allende Connelly, Migu

Fuente: http://repositorio.uchile.cl/



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