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Molecular and Cellular Therapies

, 2:30

Noncoding RNA Therapies

Abstract

MicroRNAs miRNAs are small noncoding RNAs that can function as either powerful tumor promoters or suppressors in numerous types of cancer. The ability of miRs to target multiple genes and biological signaling pathways has created intense interest in their potential clinical utility as predictive and diagnostic biomarkers, and as innovative therapeutic agents. Recently, accumulating preclinical studies have illustrated the feasibility of slowing tumor progression by either overexpressing tumor suppressive miRNAs, or by neutralizing the activities of oncogenic miRNAs in cell- and animal-based models of cancer. Here we highlight prominent miRNAs that may represent potential therapeutic targets in human malignancies, as well as review current technologies available for inactivating or restoring miRNA activity in clinical settings.

KeywordsAntisense oligonucleotides Biomarkers Chemotherapeutics Locked nucleic acids MetastamiR Metastasis microRNA OncomiR AbbreviationsAgoArgonaute

BMPBone morphogenetic protein

CDKCyclin-dependent protein kinase

DNMT3DNA cystosine-5-methyltransferase 3

HCVHuman cytomegalovirus

EMTEpithelial-mesenchymal transition

HOXD10Homeobox D10

IFNγInterferon-γ

IL-6Interleukin-6

ITGA3α3 integrin

ITGA5α5 integrin

HMGA2High mobility group AT-hook 2

LIFRLeukemia inhibitory factor receptor

lncRNALong noncoding RNA

miRNAMicroRNA

MMPMatrix metalloproteinase

MT1-MMPMembrane-type 1 MMP

NF-κBNuclear factor-κB

RDXRadixin

SBESmad-binding element

TGF-βTransforming growth factor-β

TICTumor-initiating cell

Tsp1Thrombospondin-1

uPARUrokinase-type plasminogen activator receptor

3′UTR3′-untranslated region

WAVE3WAS protein family member 3.

Electronic supplementary materialThe online version of this article doi:10.1186-2052-8426-2-30 contains supplementary material, which is available to authorized users.

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Autor: Molly A Taylor - William P Schiemann

Fuente: https://link.springer.com/



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