Control of Cell Migration in the Zebrafish Lateral Line: Implication of the Gene -Tumour- Associated Calcium Signal Transducer,- tacstdReportar como inadecuado




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Resumen

The sensory organs of the zebrafish lateral-line system neuromasts originate from migrating primordiathat move along precise pathways. The posterior primordium, which deposits the neuromasts on the bodyand tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail.This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, andby its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe anotherzebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for amembrane protein that is homologous to the TACSTD1-2 mammalian proteins. Inactivation of the zebrafishtacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for thedeposition process.



Autor: Villablanca, Eduardo J.; - Renucci, Armand; - Sapéde, Dora; - Lec, Valérie; - Soubiran, Fabien; - Sandoval, Pablo C.; - Dambly-

Fuente: http://repositorio.uchile.cl/



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