Risk for lung cancer in workers exposed to benzidine and-or beta-naphthylamine: a protocol for systematic review and meta-analysisReport as inadecuate

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Systematic Reviews

, 3:112

First Online: 03 October 2014Received: 05 August 2014Accepted: 24 September 2014DOI: 10.1186-2046-4053-3-112

Cite this article as: Tomioka, K., Saeki, K., Obayashi, K. et al. Syst Rev 2014 3: 112. doi:10.1186-2046-4053-3-112


BackgroundRisk for lung cancer in workers exposed to benzidine BZ and-or beta-naphthylamine BNA, which are well-known bladder carcinogens, has been examined in many epidemiological studies, but individual epidemiological studies generally lack the power to examine the association between BZ-BNA exposure and lung cancer. We conduct a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ-BNA occupationally.

Methods-designStudies will be identified by a MEDLINE, EMBASE, CDSR, and CINAHL search and by the reference lists of articles-relevant reviews. Eligible studies will be cohort and case-control studies that report occupational BZ-BNA exposure and the outcome of interest lung cancer death-incidence. The method of meta-analysis will be used to combine standardized mortality ratios SMRs and-or standardized incidence ratios SIRs from retrospective and prospective cohort studies and odds ratios ORs from case-control studies. Two reviewers will independently screen articles, extract data, and assess scientific quality using standardized forms and published quality assessment tools tailored for each study design. Overall pooled risk estimates and their corresponding 95% confidence intervals CIs will be obtained using random effects model. This systematic review and meta-analysis will be conducted following the Meta-analysis of Observational Studies in Epidemiology MOOSE guidelines, and results will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA statement.

DiscussionThis review will identify and synthesize studies of the association between occupational BZ-BNA exposure and lung cancer. The findings will help to identify whether BZ-BNA could cause lung cancer and might indicate whether workers with exposure to BZ-BNA have a need for preventive measures against non-urological cancer besides bladder cancer.

Systematic review registrationPROSPERO CRD42014010250

KeywordsBenzidine Beta-naphthylamine Lung cancer Mortality Incidence Occupational exposure Systematic review Meta-analysis Protocol AbbreviationsBZbenzidine


CDSRCochrane Database of Systematic Reviews

95% CI95% confidence interval

CINAHLCumulative Index to Nursing and Allied Health Literature

EMBASEExcerpta Medica DataBase

IARCInternational Agency for Research on Cancer

MOOSEMeta-analysis of Observational Studies in Epidemiology

NOSNewcastle-Ottawa scale

ORodds ratio

PRISMAPreferred Reporting Items for Systematic Reviews and Meta-analyses

PROSPEROInternational prospective register of systematic reviews

RCTrandomized controlled trial

SIRstandardized incidence ratio

SMRstandardized mortality ratio.

Electronic supplementary materialThe online version of this article doi:10.1186-2046-4053-3-112 contains supplementary material, which is available to authorized users.

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Author: Kimiko Tomioka - Keigo Saeki - Kenji Obayashi - Yuu Tanaka - Norio Kurumatani

Source: https://link.springer.com/

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