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BMC Cancer

, 14:744

Clinical oncology

Abstract

BackgroundPeripheral blood monocyte count is an easily assessable parameter of systemic inflammatory response. The aim of this study was to determine whether monocyte count was prognostic in hepatocellular carcinoma HCC following hepatic resection.

MethodsWe retrospectively reviewed 351 patients with HCC treated with hepatic resection from 2006 to 2009. Preoperative absolute peripheral monocyte count, demographics, and clinical and pathological data were analyzed.

ResultsOn univariate and multivariate analysis, elevated monocyte counts ≥545-mm, tumor size ≥5 cm, non-capsulation, and multiple tumors were associated with poor disease-free survival DFS and overall survival OS. The 1-, 3- and 5-year DFS rates were 58%, 41% and 35%, respectively, for patients with monocyte counts <545-mm, and 36%, 23% and 21% for patients with monocyte counts ≥545-mm. Correspondingly, the 1-, 3- and 5-year OS rates were 79%, 53% and 46% for monocyte counts <545-mm, and 64%, 36% and 29% for monocyte counts ≥545-mm. Subgroup analysis indicated that DFS after hepatic resection in hepatitis B virus HBV-infected patients was significantly better in those with a peripheral blood monocyte counts <545-mm, but it did not differ between patients without HBV infection. In addition, DFS was significantly better for patients with a peripheral blood monocyte count <545-mm, whether or not cirrhosis was present. Patients with elevated monocyte counts tended to have larger tumors.

ConclusionsElevated preoperative monocyte count is an independent predictor of worse prognosis for patients with HCC after hepatic resection, especially for those with HBV infection. Postoperative adjuvant treatment might be considered for patients with elevated preoperative monocyte counts.

KeywordsHepatocellular carcinoma Monocyte Hepatic resection Prognosis AbbreviationsAFPα-fetoprotein

CTComputed tomography

DFSDisease-free survival

GPSGlasgow prognostic score

HBVHepatitis B virus

HCCHepatocellular carcinoma

MRIMagnetic resonance imaging

NLRNeutrophil lymphocyte ratio

OSOverall survival

PIAFCisplatin, interferon-α, doxorubicin, and 5-fluorouracil

PLRPlatelet lymphocyte ratio

PVTTPortal vein tumor thrombus

ROCReceiver operating characteristic

TACETranscatheter arterial chemoembolization

TAMTumor-associated macrophage.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-744 contains supplementary material, which is available to authorized users.

Shun-Li Shen, Shun-Jun Fu contributed equally to this work.

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Autor: Shun-Li Shen - Shun-Jun Fu - Xiong-Qing Huang - Bin Chen - Ming Kuang - Shao-Qiang Li - Yun-Peng Hua - Li-Jian Liang - Bao

Fuente: https://link.springer.com/







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