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BMC Cancer

, 14:788

Epidemiology, prevention and public health

Abstract

BackgroundBreast cancer BC is the most common malignancy and the leading cause of cancer-related death amongst women worldwide. The risk factors of this disease are numerous, and their prevalence varies between racial and ethnic groups as well as geographical regions. Therefore, we sought to delineate the association of socio-demographic, reproductive and life-style related risk factors with breast cancer in the Arab population.

MethodsUnmatched case-control study was conducted in the kingdom of Saudi Arabia using 534 cases of histologically confirmed breast cancer and 638 controls. Controls were randomly selected from primary health care visits and were free of breast cancer. Unconditional logistic regression analysis was performed to estimate odds ratios ORs and to examine the predictive effect of each factor on risk for BC. All study participants were interviewed by trained interviewers at hospital cases or at primary health care centers controls.

ResultsA total of 1172 women were eligible for this study, of which 281 24.0% were aged ≤35 years, 22.9% illiterate, 43.6% employed, 89.5% married, and 38.1% were obese. Grade III tumors constituted 38.4% of cases. Tumor stage I was 7.5%; II, 50.7%; II, 30.9%; IV, 11.1%. We have shown strong association between breast cancer among Arab females and obesity OR =2.29, 95% CI 1.68-3.13, positive family history of breast cancer OR =2.31, 95% CI 1.60 – 3.32, the use of hormonal replacement therapy OR =2.25, 95% CI 1.65 – 3.08, post-menopause OR =1.72, 95% CI 1.25 – 2.38, lack of education OR =9.09, 95% CI 5.88 – 14.29, and never breastfeed OR =1.89, 95% CI 1.19 – 2.94.

ConclusionThese results indicate the presence of classical risk factors established in the western countries, and also some specific ones, which may result from genetic and-or environmental factors. Thereby, these findings will be of great value to establish adequate evidence-based awareness and preventative measures in the Arab world.

KeywordsBreast cancer Obesity Risk factors Epidemiology Arab women Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-788 contains supplementary material, which is available to authorized users.

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Autor: Naser Elkum - Taher Al-Tweigeri - Dahish Ajarim - Ali Al-Zahrani - Suad M Bin Amer - Abdelilah Aboussekhra

Fuente: https://link.springer.com/







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