Seroprevalence of hepatitis B and C viruses and risk factors in HIV infected children at the felgehiwot referral hospital, EthiopiaReport as inadecuate

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BMC Research Notes

, 7:838

Infectious Diseases


BackgroundLiver hepatitis due to Hepatitis B HBV and hepatitis C virus HCV co-infection is the leading cause of morbidity and mortality in HIV infected children and it is more severe in resource poor settings. Data on seroprevalence of HBV and HCV among HIV infected children are scarce in Ethiopia. This study was conducted to determine seroprevalence and risk factors of HBV and HCV and its effect on liver enzyme among HIV-positive children aged 18 months to 15 years attending the paediatric HIV care and treatment clinic at Felege Hiwot referral hospital, Ethiopia.

MethodsA cross-sectional study was conducted in May, 2014. Demographic and risk factors were collected using a structured questionnaire. Hepatitis B surface antigen HBsAg and anti-HCV antibodies were detected using an enzyme linked immunosorbent assay ELISA. Alanine aminotransferase ALT levels were determined. The results were analyzed using descriptive and logistic regression.

ResultsA total of 253 HIV positive children, boys 52.5% and girls 47.5% took part in the study. The median age of the children was 11 years. Overall, 19 7.5% of HIV infected children were positive either for HBsAg or anti-HCV antibodies. The seroprevalence of HBV and HCV were 2.0% and 5.5%, respectively. All HBsAg positive children were in older age groups 11-15years. Seroprevalence of HCV was higher in children from urban 7.7% than rural 1.2% residents P = 0.02. Overall, 29 12.1% of children had elevated ALT. Of these, 31.5% were from HBsAg or anti-HCV antibody positive children whereas 9.8% were from hepatitis B or C virus negative children P = 0.001. Multivariate logistic regression showed that being positive for HBsAg or anti-HCV antibody AOR: 4.795% CI: 1.5-13.5 was significantly associated with elevated ALT.

ConclusionHBV and HCV co-infections are common in HIV positive children. In HIV positive children, HBV and HCV co-infection were associated with elevate ALT. Routine screening for HBV and HCV in HIV infected children should be implemented.

KeywordsHBV HCV HIV ALT Children  Download fulltext PDF

Author: Bayeh Abera - Yohanes Zenebe - Wondemagegn Mulu - Mulugeta Kibret - Getachew Kahsu


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