The probability of involvement of human papillomavirus in the carcinogenesis of bladder small cell carcinoma, prostatic ductal adenocarcinoma, and penile squamous cell carcinoma: a case reportReportar como inadecuado




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BMC Research Notes

, 7:909

Urology

Abstract

BackgroundHuman papillomavirus is associated with urogenital carcinogenesis such as penile and uterine cervix cancer. On the other hand, association between human papillomavirus infection and risk of bladder and prostatic cancer remains controversial.

Case presentationWe report a rare case of a 67-year-old Japanese man with synchronous triple urogenital cancer including bladder small cell carcinoma, prostatic ductal adenocarcinoma, and penile squamous cell carcinoma, who presented with a history of asymptomatic gross hematuria. Bladder small cell carcinoma and prostatic ductal adenocarcinoma were diagnosed by histopathological examination after transurethral resection of the tumor. Moreover, he was diagnosed with penile carcinoma based on the exfoliative cytodiagnosis of nodular and papillary tumors inside the preputial collar. He was treated with laparoscopic radical cystectomy, urethrectomy, partial penectomy with pelvic lymph node dissection, and ileal conduit urinary diversion.

To identify a common pathogenesis, we considered human papillomavirus as an etiologic factor because it is a known risk factor for penile carcinoma. Human papillomavirus deoxyribonucleic acid bands were detected by polymerase chain reaction in the three tumors. There was a possibility that human papillomavirus was involved in the carcinogenesis of the triple cancer.

ConclusionsTo the best of our knowledge, this is the first report of the synchronous triple urogenital cancer of small cell carcinoma of the bladder, ductal adenocarcinoma of the prostate and penile squamous cell carcinoma. We believe that human papillomavirus may have been involved in the carcinogenesis of the triple urogenital cancer described in this case.

KeywordsSmall cell carcinoma of the bladder Prostatic ductal adenocarcinoma Penile squamous cell carcinoma Human papillomavirus AbbreviationsSmCCBSmall cell carcinoma of the bladder

DAPDuctal adenocarcinoma of the prostate

SCCPenile squamous cell carcinoma

HPVHuman papillomavirus

TURTransurethral resection

HEHematoxylin and eosin

CDCluster of differentiation

PCRPolymerase chain reaction

DNADeoxyribonucleic acid

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-909 contains supplementary material, which is available to authorized users.

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Autor: Soichiro Ogawa - Takahiro Yasui - Kazumi Taguchi - Yukihiro Umemoto - Yoshiyuki Kojima - Kenjiro Kohri

Fuente: https://link.springer.com/







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